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Viruses and Viral Diseases

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Epstein-Barr Virus (EBV) Infection

EBV is a herpesvirus responsible for infectious mononucleosis (glandular fever). It is widespread in Sri Lanka, affecting children and young adults, but often goes undiagnosed or misdiagnosed.


Symptoms of EBV Infection

  • Prolonged fever
  • Sore throat and swollen tonsils
  • Enlarged lymph nodes (especially neck)
  • Fatigue lasting weeks
  • Occasionally rash and liver involvement

Diagnosing EBV

Blood tests look for EBV-specific antibodies such as:

  • Viral Capsid Antigen (VCA) IgM: indicates recent infection
  • VCA IgG: indicates past infection
  • EBV Nuclear Antigen (EBNA): appears later, indicates past infection

Why EBV Can Be Confusing

  • Symptoms overlap with other viral infections.
  • Lab results may be unclear without clinical context.
  • In Sri Lanka, lack of awareness leads to delayed diagnosis.

When to Consult a Virologist

  • Persistent unexplained fever with lymphadenopathy
  • Confusing or conflicting test results
  • Suspected complications or immune suppression